A quest is an expedition, mission, or a goal that is given to a player, which they have the option to complete. Quests often offer some sort of reward, such as experience, money, or items.
Main quests
Beginning
- Jyhad for Beginners – Escape certain death from the Sabbat, and learn the ropes from Jack.
Santa Monica
- Wherefore Art Thou, Mercurio? – The fledgling is tasked with finding LaCroix's agent, Mercurio.
- Surf's Up – Retrieve the waylaid Astrolite from drug dealers in the beach house.
- Explosive Beginning – Persuade Therese Voerman to cease the feud between herself and Bertram Tung.
- The Ghost Haunts at Midnight – Retrieve an item from the Ocean House hotel for Therese.
- Slashterpiece – Destroy the paintings inside the Gallery Noir for Jeanette Voerman.
- Bad Blood – The fledgling is sent to reassure Jeanette that Therese does not mean to harm her.
- Sibling Rivalry – Jeanette and Therese, at each other's throats, must be persuaded to stand down.
Downtown
- Elizabethan Rendezvous – The fledgling is tasked with investigating the Elizabeth Dane, and acquiring information about the Ankaran Sarcophagus.
- Calling Dr. Grout – The Malkavian primogen, Alistair Grout, has been remiss in contacting the Prince. LaCroix wants the fledgling to investigate.
- Patron of the Ancient Arts – Retrieve the Ankaran Sarcophagus from the Museum of Natural History.
- The Epic of the Ankaran Sarcophagus – The fledgling jumps through hoops while trying to recover the Ankaran Sarcophagus.
Hollywood
- Dead Ex – Recover a partial snuff film from a courier who has backed out of the deal.
- Snuff Is Enough – The other half of the snuff film is located inside Death Mask Productions' offices.
- Going the Way of Kings – The fledgling's first introduction to a Tzimisce.
- I Spy Barabus – Gary Golden won't scratch the fledgling's back until they've scratched his, by finding one of his Nosferatu agents, Barabus.
Chinatown
- Kikinapped – Wong Ho won't help until the fledgling rescues his daughter, who has been abducted by the Tong.
- Original Gangster – With new clues concerning Barabus, the fledgling heads to Zhao's Imports for help from Wong Ho's "friend", Zhao.
- Dragon's Tail – Inquire about Barabus in the nightclub Glaze.
- Come Into My Parlor – Time to visit the mysterious Mandarin.
- Italian Dinner – Infiltrate the Giovanni Stronghold to obtain the long-sought Ankaran Sarcophagus.
Finale
- Society for the Preservation of Professors – A rescue mission is carried out for Dr. Ingvar Johansen, the only authority on the Ankaran Sarcophagus' origin and design.
- Hell at the Hallowbrook Hotel – The Sabbat launch an attack on Venture Tower.
- The Enemy of My Enemy – Find both Nines and a werewolf in Griffith Park's hilltop observatory.
- Out for Blood – LaCroix has issued a Blood Hunt on the fledgling.
- Ming Must Die! – Travel to Chinatown's Golden Temple to deal with Ming Xiao once and for all.
- Royal Flush – Travel to Downtown's Venture Tower to deal with Sebastian LaCroix once and for all.
Side quests
Santa Monica
- The Regent's Riddle – Find Maximillian Strauss, the Tremere regent.
- Carnival of Death – Find out more about the serial killer and take care of him.
- The Pain of Being Mercurio – Mercurio is in need of some serious painkillers.
- Drug Trip – Get Trip some drugs. (Unofficial Patch Plus only)
- Trick or Treatment – A girl is dying in the Santa Monica clinic.
- Daydream Believer – "Help" one of the thin bloods with his vampirism.
- Thinned Blood – Find Lily for E.
- Replanting a Lily – Find for Vandal Cleaver replacement of Lily.
- The Hunted Hunter – Destroy the "Asian Vampire" that Knox Harrington told you about.
- A Bounty for the Hunter – Find Arthur Kilpatrick's bounty hunter, Carson.
- Jumpin' the Bail – Arthur Kilpatrick wants you to find out what is going on with Mike Durbin.
- Bloody Mess – Retrieve the Werewolf Blood from the Santa Monica blood bank.
- Spiritual Release – Deliver the pendant from the Ocean House Hotel to Therese or Jeanette Voerman.
- Mudd Hunt – Locate Mike Durbin for Arthur Kilpatrick.
- Missing Data – Bertram Tung wants to get back his lost data CD. (Nosferatu only unless you are using Unofficial Patch)
Downtown
- Traffik – Steal a briefcase from the Asian gang for Fat Larry.
- A Plague for the Angels – Take care of the plaguebearers for Maximillian Strauss and/or Damsel.
- Fun With Pestilence – Find Paul Anderson and take care of Jezebel Locke.
- Attention Whore – Deal with the ghoul named Patty.
- More Fun With Pestilence – Find and destroy Bishop Vick.
- Necromantic – Deal with the reporter Simon Milligan for Pisha to protect the Masquerade.
- A Confession – Solve Venus Dare's money problems with the Russians.
- And Her Name Was Venus – Solve Venus' problem with Boris Checkov.
- Venucide – Kill Venus for Boris.
- Occultish Personality – Retrieve occult items for Pisha.
- Night at the Library – Interrupt the Sabbat ritual and kill the Lasombra for Beckett. (Unofficial Patch Plus only)
- Ash to Ashes – Rescue Ash from the hunters in the Society of Leopold. (Unofficial Patch Plus only)
Hollywood
- Hot Stripper Assassin Action! – Eliminate the vampire hunter Chastity for Velvet Velour.
- B-Rated Writer – Retrieve David Hatter's screenplay for Velvet Velour and find out who's his collaborator.
- Hunters Hunting – Help Ash Rivers with his vampire hunters problem.
- You Only Die Once a Night – Romero asks you to guard the cemetery while he's absent.
- Pimpin' for Romero – Romero needs some loving.
- A Dish Best Served Cold – LaCroix wants to see the Cavoletti Café's bad review.
- Gargoyle Removal Service – Solve the Gargoyle problem for Isaac Abrams.
- A Tangled Web – Help Mitnick with building the Nosferatu network in Los Angeles.
- Model Citizen – Imalia tasks fledging with setting cameras in Tawni Sessions' apartment.
- Cover Girl – Imalia wants you to find her a copy of Guy magazine.
- Poster Session – Gary Golden offers you some posters in exchange for items.
Chinatown
- Gone Fishin' – Help Yukie with the hengeyōkai demon problem.
- Eye Gouge Hell – Retrieve Lin's eyes for Mr. Ox.
- Bad Luck Farmer – Place the Bad Luck Talisman in a Lotus Blossom locker for Mr. Ox.
- The Hitman Impasse – Lu Fang and Ji Wen Ja want to kill each other.
- Dirty Dishes – Help Mira Giovanni with displacing candidates in a competition.