Some indeterminate time prior to the game's events, Zygaena had killed Yukie's master, prompting her to avenge him. Zygaena later traveled to Los Angeles, where he would then meet his demise at the hands of Yukie, and the fledgling. He also seemed to respect Ming Xiao, as he announced his presence in her city.
As a hengeyōkai, Zygaena is a very powerful and dangerous being, having the ability to change his shape at will. He can turn into a bipedal, thus capable of inflicting large amounts of damage.
- Though never mentioned in the game, the article "Bloodlines Primer" by  states that he's of the breed.
- His name might be a reference to the smooth hammerhead (Sphyrna zygaena) species.
- As a Ventrue, the player will be able to attempt to dominate Zygaena during conversation. This will, however, not affect him whatsoever.
- As a Malkavian, the player will be able to attempt to use Dementation on Zygaena during conversation. Like dominate, this does not appear to affect him.